Dr. DEBPRASAD CHATTOPADHYAY

Scientist G, Director

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Dr Debprasad Chattopadhyay is serving as Director & Scientist G at ICMR-National Institute of Traditional Medicine, Belagavi Karnataka since August 2016, after serving ICMR-Virus Unit, Kolkata since 1997. He has obtained PhD from Jadavpur University in 1989 after Post-Graduation in in Botany with Microbiology; and attended the London Hospital Medical College and Staten’s Serum Institute Copenhagen for Post-Doctoral studies (1990-1992). His research field includes Traditional Medicine, Ethnomedicine, Virology, Microbiology and Molecular Medicine to identify nature-based leads against difficult-to-treat diseases through documentation and validation of purity, safety and potency (PSP) of traditional practices of Indian tribes with mode or molecular mechanism of action. His work on identifying antiviral, anti-infective, anti-inflammatory, immunomodulatory and contraceptive molecules from traditional practices has been highly acclaimed, with publications in Journals of repute and patents. He has established personal contact with diverse ethnic communities of Andaman to West Bengal to document and validate their age-old health-care practices to translate traditional wisdom into medical innovation. Dr Chattopadhyay is credited with 08 patents, 04 leads, 55 popular-science articles and 148 (122 International) research papers and review in peer-reviewed Journals of repute, with Chapters and Books (h-Index: 35; i10-Index: 81; Citations: 3947). He is serving as the Editor of the prestigious Frontiers in Pharmacology, Section Editor Mini Review in Medicinal Chemistry; Editorial Board Member Journal of Ethnopharmacology etc and Reviewer of 40+ peer-reviewed Journals; Examiner, PhD Guide, and visiting Faculty of Universities. He is the recipient of Outstanding Ethnopharmacologist (2016), Best Science Communicator (2009), Amiya Bose Oration 2008, RV Rajam Endowment of IMA 1998, International Society of Chemotherapy Young Scientist 1991 awards etc. Dr Chattopadhyay is the Fellow of the British Society for Antimicrobial Chemotherapy, and served in the: Interdisciplinary Technical Review Committee of COVID-19 for Patent & Proprietary Medicines; Interdepartmental Committee for identifying viable new system of medicine, Govt of India; Interdisciplinary AYUSH Research & Development Task Force Working Group; DST-SERB Project Advisory Committee; DST-SERB Young Scientist LS Expert Committee; Board of Studies of Pharmaceutical Technology, Jadavpur University; Research Advisory Board, Chemical Technology, Calcutta University etc. So far he has produced 17 PhDs and completed 17 National Task Force Projects on ethnomedicines of marginalized communities of India, and is the member of Review and Approval Committee of several funding agencies. He successfully established a state-of-art RT-PCR diagnostic COVID-19 lab at ICMR-NITM with the help of Govt. of Karnataka, that tested more than 2.2 lakh samples so far, to serve the people during unprecedented pandemic. He has published eight scientific articles on COVID-19 and is engaged in the work on traditional herbal formula to combat Covid-19 infection.

Top publications in reputed and peer reviewed journals

Published:148 (National 30, International 118: Review 5, Chapter 14, Book 4; Editor: 05). H-Index: 35; i10-Index: 81; Impacts: 577.7; Citations: 3947 [First/Corresponding Author in Indexed Journals: 95; Co-Author in Indexed Journals: 27 Books, Chapter and other publications: 26].

1. Kumar B, Misra A. Singh SP, Dhar YV, Rawat P, Chattopadhyay D, Srivastava S, Barik S K (2021). In-silico efficacy of potential phytomolecules from Ayurvedic herbs as an adjunct therapy in management of Covid-19. Journal of Food and Drug Analysis. JFDA-D-21-00228. Impact Factor: 6.079. 2. Kalkal M, Tiwari M, Thakur RS, Awasthi V, Pande V, Chattopadhyay D, Das J (2021). Mesenchymal stem cells: A novel therapeutic approach to enhance protective immunomodulation and erythropoietic recovery in malaria. Stem Cell Reviews and Reports. 2021. June 12: 1-10. doi: 10.1007/s12015-021-10191-1 Impact Factor: 5.739

2. Kalkal M, Tiwari M, Thakur RS, Awasthi V, Pande V, Chattopadhyay D, Das J (2021). Mesenchymal stem cells: A novel therapeutic approach to enhance protective immunomodulation and erythropoietic recovery in malaria. Stem Cell Reviews and Reports. 2021. June 12: 1-10. doi: 10.1007/s12015-021-10191-1 Impact Factor: 5.739

3. Mandal J, Das Mahapatra A, Mandal KC, Chattopadhyay D (2021). Extracts of Stephania hernandifolia, an ethnomedicinal plant, inhibits HSV-1 entry. Archives of Virology (2021). https://doi.org/10.1007/s00705-021-05093-z. Impact Factor: 2.160

4. Palit P, Mukhopadhyay A, Chattopadhyay D (2021). Phyto-pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for COVID-19, based on its promising immuno-modulatory, anti-coagulant and anti-viral property. Phytotherapy Research. 04 April 2021. https://doi.org/10.1002/ptr.7084. Impact Factor: 4.087

5. Umashankar V, Deshpande SH, Hegde HV, Singh I, Chattopadhyay D (2021). Phytochemical moieties from Indian traditional medicine for targeting dual hotspots on SARS-CoV-2 spike protein: An integrative in-silico approach. Frontiers in Medicine 8: 672629. doi: 10.3389/fmed.2021.672629 Impact Factor: 3.90

6. Naik SR, Bharadwaj P, Dingelstad N, Kalyaanamoorthy S, Ganesan A, Chattopadhyay D, Palit P (2021). Structure-based virtual screening, molecular dynamics and binding affinity calculations of some potential phytocompounds against SARS-CoV-2. J Biomolecular Structure & Dynamics. 2021 Mar 8; 1-18. doi.org/10.1080/07391102.2021.1891969. Impact Factor: 4.986

7. Singh I, Umashankar V, Harish DR, Chattopadhyay D (2021). Coding-Complete Genome Sequences of NITM-A1086 and NITM-A1139, two SARS-CoV-2 Isolates from Belagavi District, Karnataka State, India harbouring the D614G mutation. Microbiology Resource Announcement, American Society for Microbiology. 10(6): e00016-21. DOI: 10.1128/MRA. 00016-21. Impact Factor: 4.25

8. Palit P, Chattopadhyay D, Thomas S, Kundu A, Kim HS, Rezaei N (2020). Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19? Phytomedicine 85: 153396. 2021 May. Doi: 10.1016/j. phymed.2020.153396. Published online 2020 Oct 28. Impact Factor: 4.268.

9. Bhaskar Ashima, Kumari Anjna, Singh Mona, Kumar S, Chaturvedi S, Yadav V, Chattopadhyay D. Dwivedi VP (2020). [6]-Gingerol displays anti-mycobacterial and immunomodulatory activity against pulmonary tuberculosis. International Immuno-pharmacology 87: 106-809. DOI: 10.1016/j.intimp.2020.106809. Impact Factor: 3.943

10. Patidar A, Selvaraj S, Chauhan P, Guzmán C, Ebensen T, Sarkar A, Chattopadhyay D, Saha B (2020). Peptidoglycan-treated tumor antigen-pulsed dendritic cells impart complete resistance against tumor rechallenge. Clinical and Experimental Immunology 201(3): 279-288. doi: 10.1111/cei.13468. Epub 2020 Jun 26. Impact Factor: 3.532

11. Bodhale NP, Sarkar A, Chattopadhyay D, Saha B, Bhattacharyya M (2020). Metabolic regulation of cytokine production in Leishmania resistance and susceptibility. Journal of Immunology 204 (S1): 73.6. May 1, 2020. Impact Factor: 4.718

12. Kumar S, Sharma C, Kaushik S, Kulshreshtha A, Chaturvedi S, Nanda R, Bhaskar A, Das G, Chattopadhyay D, Dwivedi VP (2019). Phytochemical Bergenin as an Adjunct Immunotherapy for Tuberculosis. Journal of Biological Chemistry 294: 8555-8563. Doi: 10.1074/jbc.RA119. 008005. Epub 2019 Apr 11. Impact Factor: 4.010

13. Goswami D, Das Mahapatra A, Banerjee S, Kar A, Ojha D, Mukherjee PK, Chattopadhyay D (2018). Boswellia serrata oleo gum-resin and β-boswellic acid inhibits HSV-1 infection through modulation of NFкB and p38 MAP kinase signaling. Phytomedicine 51: 94-103. Doi: 10.1016/j. phymed.2018.10.016. Epub 2018 Oct 16. Impact Factor: 4.18

14. Halder A, Das Suvadra, Ojha D, Chattopadhyay D, Mukherjee A (2018). Highly Monodispersed Gold Nanoparticles synthesis and Inhibition of Herpes Simplex Virus infections. Materials Science and Engineering: C 89 413-421. Doi: 10.1016/j.msec.2018.04. 005. Epub 2018 Apr 5 Impact Factor: 5.88

15. Chattopadhyay D, Ojha D, Mukherjee H, Bag P, Vaidya SP, Dutta S (2018). Validation of a Traditional Preparation against Multi-drug resistant S. Typhi and its Protective Efficacy in S. Typhimurium infected Mice. Biomedicine and Pharmacotherapy 99: 286-289. Doi: 10.1016/j. biopha.2018.01.057. 2018 March. Impact Factor: 4.545

16. Dwivedi VP, Bhattacharya D, Yadav V, Singh DK, Kumar S, Singh M, Ojha D, Ranganathan A, Kaer LV, Chattopadhyay D, Das G (2017). The phytochemical Bergenin enhances T helper-1 responses and anti-Mycobacterial immunity by activating the MAP kinase pathway in macrophages. Frontiers in Cellular and Infection Microbiology 7: Article 149, 9 pages. Doi: 10.3389/fcimb.2017. 00149.IF: 6.04

17. Bag P, Ojha D, Mukherjee H, Halder UC, Mondal S, Biswas A, Sharon A, Luc Van K, Chakraborty S, Das G, Mitra D, Chattopadhyay D (2014). A Dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering with the viral immediate early transcriptional events. Antiviral Research 105:126-134. Doi: 10.1016/j.antiviral.2014.02.007. Epub 2014 Feb 25. Impact Factor: 4.909

18. Chatterjee S, Dwivedi VP, Singh Y, Siddiqui I, Sharma P, Kaer LV, Chattopadhyay D, Das G (2011). Early Secreted Antigen ESAT-6 of Mycobacterium tuberculosis Promotes Protective T Helper 17 Cell Responses in a Toll-Like Receptor-2-dependent Manner. PLoS Pathogen 7(11): e1002378. Doi: 10.1371/journal.ppat.1002378. Epub 2011 Nov 10. Impact Factor: 9.127

19. Chattopadhyay D, Khan MTH (2008). Ethnomedicines and Ethnomedicinal Phytophores against Herpes viruses. Chapter 17, Biotechnology Annual Review 14: 297-348. DOI: 10.1016/S1387-2656(08) 00012-4.2008 Feb.

20. Chattopadhyay D, Dungdung SR, Majumder GC, Bhattacharya SK, Mandal AB (2005). A potent sperm motility inhibiting bioflavonoids from an Ethnomedicine of Onge, Alstonia macrophylla Wall ex A. DC. Leaf extract. Contraception 71(5) 372-378. DOI: 10.1016/j.contraception.2004.11. 006 Impact Factor: 3.09

21. Chattopadhyay D, Arunachalam G, Mandal AB, Mandal SC (2002). Evaluation of antipyretic activity of leaf extracts of Mallotus peltatus (Geist) Muell. Arg: a folklore medicine. Phytomedicine 9(8) 727-730. DOI: 10.1078/094471102321621331 2002 Dec. Impact Factor: 4.18

22. Minassian MA, Lewis DA, Chattopadhyay D, Bovill B, Duckworth GJ, Williams JD (1998). A comparison between single-dose Fosfomycin trometamol (MonrillR) and a 5-day course of trimethoprim in the treatment of uncomplicated lower urinary tract infection in women. International J Antimicrobial Agents 10(1) 39-47. Impact Factor: 4.621

23. Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). Altered membrane permeability as the basis of bactericidal action of methdilazine. J Antimicrobial Chemotherapy 42 83-85. Impact Factor: 5.313

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