Aimed to provide practice-based evidence, models and frameworks for integrating traditional medicinal practices into a rapidly evolving health delivery system the Department of Health Systems Research has recently been established in January 2022. It works for clinical validation of traditional medicines used in communities. Evaluating efficacy/effectiveness and safety of traditional medicine through pharmacoepidemiological studies; pharmacovigilance of non-codified traditional practices; understanding perception of patients visiting traditional healers, implementation/operational research are some of the key areas of interest in this Department. Apart from serving as a bridge between traditional and modern systems of medicine, the Health Systems Research Department is also mandated to carry out research on diseases of National and regional importance. The Department is particularly active on rural health problems through its research carried out at Model Rural Health Research Unit, Raichur in collaboration with the State Health authorities and the Government Medical Colleges in the Kalyana Karnataka region.